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Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · Oncology, Hematology, Pediatrics +1 moreMedium impact

Hematopoietic Cell Transplantation for Solid Tumors of Childhood

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Autologous hematopoietic cell transplantation may be considered medically necessary at initial treatment of high-risk neuroblastoma and high-risk Ewing sarcoma, for recurrent or refractory neuroblastoma and Ewing sarcoma, and for metastatic retinoblastoma. Tandem autologous transplant may be considered medically necessary for high-risk neuroblastoma. Autologous transplant is considered investigational as initial treatment of low- or intermediate-risk neuroblastoma and Ewing sarcoma and for rhabdomyosarcoma, Wilms tumor, osteosarcoma and retinoblastoma without metastasis, and allogeneic transplant for pediatric solid tumors and salvage allogeneic transplant after relapse or failure of response to autologous transplant are considered investigational.

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What to do

Action · 5 steps
01Billing team: Before billing a covered transplant procedure or transplant evaluation for these solid tumors, confirm the member received prior authorization through Case Management from Blue Cross & Blue Shield of Mississippi, since no benefits will be provided without it.
02For State and School Employee subscribers, confirm the transplant was certified as medically necessary by the Plan's Utilization Review Vendor and that prior approval was obtained from the Plan's Utilization Review Vendor, since no benefits will be provided for any transplant procedure without that approval.
03For Federal Employee Program subscribers, check the Service Benefit Plan's specific conditions under which autologous or allogeneic transplants are eligible for coverage.
04Bill S2150 only for autologous stem-cell support, since only autologous stem-cell support is covered.
05The listed codes are only medically necessary when the procedure is performed according to the Policy section, so confirm the indication matches a medically necessary statement in that section.

Codes mentioned

38204382053820638207382083820938210382113821238213382143821538220382213822238230382403824138242868128681386816868178682186825868269640196402964059640696409964119641396415964169641796420964229642396425964409644696450965219652296523Q0083Q0084Q0085S2150C38.1C38.2C38.3C38.8C40.00C41.9C47.4C49.4C49.A0C49.A9C74.00C74.92C76.00C76.2C76.3C78.1C79.51C79.52C79.89C79.9C96.4C96.9C96.Z

Original notice

Hematopoietic Cell Transplantation for Solid Tumors of Childhood
bcbsms.com · Always check the source before changing claims.
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