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AetnaAll Plans · Coverage · Medical Policy · Ophthalmology, OncologyMedium impact

Transpupillary Thermal Therapy (CPB 0490, reviewed 2026-10-05)

Effective date
Not stated in the notice
Identified
Oct 13, 2026

Summary

Aetna considers transpupillary thermotherapy medically necessary for retinoblastoma involving less than 50% of the retina and without associated vitreal or sub-retinal seeds at the time of thermotherapy, and for small (2 to 3 mm) choroidal melanomas located posterior in the globe. Aetna considers transpupillary thermotherapy experimental, investigational, or unproven for all other indications, including central serous chorioretinopathy, choroidal neovascularization associated with age-related macular degeneration, circumscribed choroidal hemangioma, retinopathy of prematurity and polypoidal choroidal vasculopathy. The stated reason is the lack of prospective, controlled clinical studies supporting its effectiveness for these indications.

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What to do

Action · 3 steps
01Billing team: Bill transpupillary thermotherapy for retinoblastoma only when it involves less than 50% of the retina and there are no associated vitreal or sub-retinal seeds at the time of thermotherapy, using ICD-10 codes C69.20 through C69.22.
02Billing team: Bill it for small (2 to 3 mm) choroidal melanomas located posterior in the globe, using ICD-10 codes C69.30 through C69.32.
03Billing team: Transpupillary thermotherapy, combined photodynamic therapy and TTT, and indocyanine green-enhanced TTT have no specific CPT code, and the policy lists them as not covered for the indications it names.

Codes mentioned

670286703967040672106721867220672276722867229J0178Q5155Q5170C69.20C69.22C69.30C69.32C79.49D18.09H31.8H32H35.81

Original notice

Transpupillary Thermal Therapy (CPB 0490, reviewed 2026-10-05)
aetna.com · Always check the source before changing claims.
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