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Irreversible Electroporation (NanoKnife) (CPB 0828, reviewed 2026-03-03)
Effective date
Not stated in the notice
Identified
Aug 16, 2026
Summary
This is an older Aetna clinical policy bulletin (CPB 0828) on irreversible electroporation (IRE), including the NanoKnife system for tissue ablation. It was last reviewed 03/03/2026, and its original effective date is 06/15/2012. Aetna considers IRE experimental, investigational or unproven for all indications, including the listed indications such as hepatocellular carcinoma, pancreatic cancer, prostate cancer, renal masses, lung nodules and breast cancer, because the peer-reviewed literature has insufficient evidence.
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What to do
Action · 2 steps
01Billing team: Do not bill CPT 0600T, 0601T or 47384 for the indications listed in this policy, because the policy lists these codes as not covered for those indications.
02Billing team: Do not bill IRE, including NanoKnife tissue ablation, as a covered service for the listed indications, because Aetna considers it experimental, investigational or unproven for all of them.
Codes mentioned
47384936509365593657J9299C22.1C22.8C61C76.0C76.2C78.5C78.7C78.89C79.49C79.81C79.82C79.89D32.0D44.7I48.91N28.89R91.1
Original notice
Irreversible Electroporation (NanoKnife) (CPB 0828, reviewed 2026-03-03)
aetna.com · Always check the source before changing claims.
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Related policy hubs
Aetna policiesOncologyUrologyCardiologyNeurosurgeryGastroenterologyGeneral SurgeryPulmonologyENT (Ear, Nose & Throat)OB-GYNOphthalmologyPediatricsWound CareCode 47384Code 93650Code 93655Code 93657Code J9299Code C22.1Code C22.8Code C61Code C76.0Code C76.2Code C78.5Code C78.7Code C78.89Code C79.49Code C79.81Code C79.82Code C79.89Code D32.0Code D44.7Code I48.91Code N28.89Code R91.1