Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · OB-GYN, PathologyHigh impact
Noninvasive Fetal RHD Genotyping Using Cell-Free Fetal DNA
Effective date
Jul 1, 2026
Identified
Jun 20, 2026
Summary
Measurement of cell-free DNA for fetal genotyping for RhD antigen may be medically necessary when all of the following criteria are met: the pregnancy may be at risk for alloimmunization due to maternal RhD negative status or maternal red cell antigen antibodies, paternal antigen typing is unavailable or heterozygous, and amniocentesis is declined or contraindicated. The policy history records a 10/15/2025 update that changed CPT codes 81403 and 81479 from investigational to medically necessary. Code 0632U was added to the code reference effective 07/01/2026 as a new CPT code for multiplex PCR and next-generation sequencing of circulating cell-free DNA from plasma of pregnant individuals known to be RhD negative, reported as detected or not detected.
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01Already effective 2026-07-01: Use CPT 0632U for fetal RhD gene analysis of cell-free DNA from pregnant individuals known to be RhD negative, and do not report 0632U in conjunction with 0488U.
02Billing team: Before billing CPT 81403 or 81479 for cell-free fetal RhD testing, confirm that the pregnancy may be at risk for alloimmunization, that paternal antigen typing is unavailable or heterozygous, and that amniocentesis is declined or contraindicated.
03Testing that does not meet these criteria is investigational.
04Diagnosis codes O36.0110 through O36.0199 (maternal care for anti-D antibodies) and Z31.82 (Rh incompatibility status) are listed with the medically necessary codes.
Codes mentioned
8140381479O36.0110O36.0199Z31.82
Original notice
Noninvasive Fetal RHD Genotyping Using Cell-Free Fetal DNA
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