PolicyChanges tracks payer policy changes for medical practices and tells you what to do before they take effect.

Create a free accountPolicy Monitoring is free. No card required.
← Back to list
Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · OB-GYN, OncologyMedium impact

CA-125

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

CA-125 measurement may be considered medically necessary in patients with symptoms suggestive of ovarian cancer or with known ovarian cancer. It may also be considered medically necessary for individual patients with other gynecologic malignancies, such as endometrial cancer, in whom baseline CA-125 levels have been shown to be elevated. Measurement of CA-125 is considered investigational in asymptomatic patients as a screening technique for ovarian cancer.

Get alerts when payers change rules like this one

We check Blue Cross & Blue Shield of Mississippi and other payers every day and email you when a change matches your specialty and state.

Get Blue Cross & Blue Shield of Mississippi alertsPolicy Monitoring is free. No card required.

What to do

Action · 4 steps
01Billing team: Bill CPT 86304 (immunoassay for tumor antigen, quantitative, CA 125) for patients with symptoms suggestive of ovarian cancer or with known ovarian cancer.
02Billing team: For other gynecologic malignancies, such as endometrial cancer, bill only when baseline CA-125 levels have been shown to be elevated in that patient.
03Billing team: Screening of asymptomatic patients with CA-125 for ovarian cancer is considered investigational under this policy.
04Billing team: Use ICD-10 codes from the Covered Codes list, such as R97.1 (elevated cancer antigen 125) and C56.1 - C56.9 (malignant neoplasm of ovary).

Codes mentioned

86304C56.1C56.9C79.60C79.63R97.1R97.8G89.3N83.00N83.299

Original notice

CA-125
bcbsms.com · Always check the source before changing claims.
View original ↗

Related policy hubs

Summaries are AI-assisted. Always confirm against the original payer notice.

What is PolicyChanges

One workspace for payer rules, prior auth, coding and compliance

Medical practices use PolicyChanges to catch payer changes before they cause denials. Every change is summarized in plain English, with the codes involved, the date it takes effect and what to do.

Start freePolicy Monitoring is free. No card required.
Get alerts for changes like thisPolicy Monitoring is free. No card required.Create a free account