CA-125
CA-125 measurement may be considered medically necessary in patients with symptoms suggestive of ovarian cancer or with known ovarian cancer. It may also be considered medically necessary for individual patients with other gynecologic malignancies, such as endometrial cancer, in whom baseline CA-125 levels have been shown to be elevated. Measurement of CA-125 is considered investigational in asymptomatic patients as a screening technique for ovarian cancer.