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Immune Cell Function Assay
Effective date
Not stated in the notice
Identified
Jun 20, 2026
Summary
Use of immune cell function assay testing to monitor and predict immune function after solid organ transplantation is investigational. Use of immune cell function assay testing to monitor and predict immune function after hematopoietic cell transplantation is also investigational, as is use for all other indications. The policy's investigational code list includes CPT 0018M, 81560, 82397, 86352 and 86353.
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What to do
Action · 3 steps
01Billing team: Do not bill immune cell function assay testing as medically necessary for monitoring or predicting immune function after solid organ transplantation, after hematopoietic cell transplantation, or for any other indication, because the policy considers it investigational.
02Check CPT 0018M, 81560, 82397, 86352 and 86353 against the investigational codes list before billing.
03Federal Employee Program (FEP) members: the policy notes that FEP may dictate that all FDA-approved devices, drugs or biologics may not be considered investigational, so those may be assessed only on the basis of their medical necessity.
Codes mentioned
81560823978635286353
Original notice
Immune Cell Function Assay
bcbsms.com · Always check the source before changing claims.