CommercialCoverageLow impact
Immune Cell Function Assay
Blue Cross & Blue Shield of Mississippi·Nephrology, Oncology, Hematology +3 more·Medical Policy
Effective date
Feb 10, 2025
We identified it
Jun 20, 2026
Summary
This Blue Cross Blue Shield policy confirms that immune cell function assays (ImmuKnow, Pleximmune) remain investigational and non-covered for all transplant monitoring indications. No changes were made in this policy review - it maintains the same investigational status established in previous years.
Action Required
Immediately: Billing team should verify that immune cell function assay codes (0018M, 81560, 82397, 86352, 86353) are flagged as investigational/non-covered in billing system for BCBS plans. Ensure claims are not submitted for these services as they will be denied. Inform providers that these tests are not covered by BCBS for any indication.