Ultra Rapid Detoxification (UROD) (CPB 0317, reviewed 2026-05-21)
Aetna considers ultra rapid detoxification (UROD) experimental, investigational, or unproven as a clinical detoxification treatment and for all other indications, because its effectiveness has not been established. The procedure induces opiate detoxification with a bolus of very high-dose naloxone under general anesthesia or heavy sedation, followed by a slow infusion of low-dose naloxone. There is a reported risk of serious adverse events, including death, with the use of anesthetics, and the policy's cited NICE guidance states that ultra-rapid detoxification under general anesthesia or heavy sedation must not be offered.