← Back to list
Ultra Rapid Detoxification (UROD) (CPB 0317, reviewed 2026-05-21)
Effective date
Not stated in the notice
Identified
Aug 18, 2026
Summary
Aetna considers ultra rapid detoxification (UROD) experimental, investigational, or unproven as a clinical detoxification treatment and for all other indications, because its effectiveness has not been established. The procedure induces opiate detoxification with a bolus of very high-dose naloxone under general anesthesia or heavy sedation, followed by a slow infusion of low-dose naloxone. There is a reported risk of serious adverse events, including death, with the use of anesthetics, and the policy's cited NICE guidance states that ultra-rapid detoxification under general anesthesia or heavy sedation must not be offered.
Get alerts when payers change rules like this one
We check Aetna and other payers every day and email you when a change matches your specialty and state.
Get Aetna alertsPolicy Monitoring is free. No card required.
What to do
Action · 3 steps
01Billing team: Do not bill ultra rapid detoxification (UROD) as a clinical detoxification treatment or for any other indication in this policy, because Aetna considers it experimental, investigational, or unproven.
02There is no specific CPT code for UROD.
03The ICD-10 codes listed as not covered for the indications in this policy include opioid abuse (F11.10 through F11.19), opioid dependence (F11.20 through F11.29), and poisoning by or adverse effects of opiates and related narcotics (T40.0X1 through T40.4X5, T40.601 through T40.695, and T40.3X5 for methadone).
Codes mentioned
J2312J2313F11.10F11.19F11.20F11.29T40.0X1T40.0X4T40.0X5T40.1X1T40.1X4T40.2X1T40.2X4T40.2X5T40.3X1T40.3X4T40.3X5T40.4X1T40.4X4T40.4X5T40.601T40.604T40.605T40.691T40.694T40.695
Original notice
Ultra Rapid Detoxification (UROD) (CPB 0317, reviewed 2026-05-21)
aetna.com · Always check the source before changing claims.
Related changes
See all Aetna changes →Diagnosis of Vaginitis (CPB 0643, reviewed 2025-12-15)MediumNo effective date · Medical PolicyActigraphy and Accelerometry (CPB 0710, reviewed 2026-10-15)MediumNo effective date · Medical PolicyActigraphy and Accelerometry (CPB 0710, reviewed 2025-10-14)MediumNo effective date · Medical PolicyHepatitis Screening (CPB 0835, reviewed 2025-12-09)MediumNo effective date · Medical PolicyBrowse every Aetna change in the policy list
Related policy hubs
Aetna policiesPsychiatryAnesthesiologyCode J2312Code J2313Code F11.10Code F11.19Code F11.20Code F11.29Code T40.0X1Code T40.0X4Code T40.0X5Code T40.1X1Code T40.1X4Code T40.2X1Code T40.2X4Code T40.2X5Code T40.3X1Code T40.3X4Code T40.3X5Code T40.4X1Code T40.4X4Code T40.4X5Code T40.601Code T40.604Code T40.605Code T40.691Code T40.694Code T40.695