Aetna · Identified Aug 19, 2026Medium impact
Liver Transplantation (CPB 0596, reviewed 2026-03-02)
Aetna considers orthotopic liver transplantation medically necessary for members with end-stage liver disease from the listed conditions who meet the policy's medical necessity criteria. For adolescents 12 or older and adults, the criteria are a MELD score greater than 10, approval by a UNOS Regional Review Board, or meeting the transplant institution's selection criteria. Children under 12 are covered when they meet the transplanting institution's selection criteria. The policy also covers primary hepatocellular carcinoma confined to the liver that meets listed criteria, retransplantation after a failed transplant performed for a covered indication, normothermic machine perfusion of the transplanted liver, and compatibility testing for living donors. Absolute contraindications include active sepsis outside the biliary tract, inability to adhere to the transplant regimen, and significant organ system failure other than kidney, liver or small bowel failure. Liver transplantation for malignancies other than those listed, and several perfusion, biomarker and support-system uses, are described as experimental, investigational or unproven.