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CommercialCoverageMedium impact

08.00.59d, Loncastuximab tesirine-lpyl (Zynlonta®)

Independence Blue Cross·Oncology, Hematology·Pharmacy
Effective date
Nov 17, 2025
We identified it
Jun 19, 2026
Days to comply

Summary

Commercial insurance policy for Loncastuximab tesirine-lpyl (Zynlonta®) has been updated with new medical necessity criteria and general guidelines. This affects coverage determination and billing requirements for this specialty oncology medication.

Action Required

Action needed
By November 17, 2025: Billing team must review updated medical necessity criteria for Loncastuximab tesirine-lpyl (Zynlonta®) coverage. Providers must ensure documentation meets new criteria requirements before submitting claims. Update prior authorization workflows if applicable to prevent claim denials.