Vitamin B-12 Therapy (CPB 0536, reviewed 2026-08-20)
Summary
Aetna covers intramuscular or subcutaneous vitamin B-12 injections for members with current or previously documented B-12 deficiency and a listed condition, such as pernicious anemia, malabsorption syndromes, gastrectomy, acute neuropathy due to malnutrition or alcohol use disorder, dementia secondary to B-12 deficiency, or treatment with methotrexate, pralatrexate or pemetrexed. Homocysteine testing (CPT 83090) is covered for borderline B-12 deficiency when the result will affect the member's management. Injections for all other indications are considered experimental, investigational or unproven, including depression, autism, migraine prophylaxis, diabetic peripheral neuropathy and tinnitus, and holotranscobalamin measurement is considered unproven because its clinical value has not been established.
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