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Non-invasive Measurement of Advanced Glycation End-products (CPB 0841, reviewed 2025-12-09)
Effective date
Not stated in the notice
Identified
Aug 18, 2026
Summary
Aetna considers non-invasive measurement of advanced glycation end-products (AGEs) in the skin, saliva and tears experimental, investigational, or unproven because of insufficient evidence in the peer-reviewed literature. The policy lists no specific CPT code for non-invasive measurement of AGEs. It lists diabetes mellitus diagnosis codes E08.00 through E13.9 as not covered for the indications listed in the policy. Related Aetna policies are CPB 0070 (Diabetic Tests, Programs and Supplies) and CPB 0381 (Cardiovascular Disease Risk Tests).
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What to do
Action · 2 steps
01Billing team: Do not bill non-invasive AGE measurement in the skin, saliva or tears as a covered service, because Aetna considers it experimental, investigational, or unproven.
02The policy lists no specific CPT code for this measurement, and diabetes mellitus diagnosis codes E08.00 through E13.9 are not covered for the indications listed in the policy, so do not expect coverage for AGE measurement with those diagnosis codes for those indications.
Codes mentioned
E08.00E13.9
Original notice
Non-invasive Measurement of Advanced Glycation End-products (CPB 0841, reviewed 2025-12-09)
aetna.com · Always check the source before changing claims.
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