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AetnaAll Plans · Coverage · Medical Policy · Oncology, NeurologyMedium impact

Antineoplaston Therapy (CPB 0240, reviewed 2026-04-13)

Effective date
Not stated in the notice
Identified
Aug 12, 2026

Summary

Aetna considers antineoplaston therapy (auto-urine therapy) experimental, investigational, or unproven because the effectiveness of these approaches has not been established. The following services associated with antineoplaston therapy are also listed as experimental, investigational, or unproven: ancillary diagnostic laboratory, x-rays, MRI or CT scans done to monitor the therapy; infusion pump and intravenous supplies for use with the infusion pump; placement of Hickman catheter; and oral antineoplaston therapy or associated physician services for administering and monitoring oral antineoplaston treatment. Antineoplaston therapy is not approved by the Food and Drug Administration (FDA) for any indication.

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What to do

Action · 3 steps
01Billing team: Do not bill antineoplaston therapy (auto-urine therapy) as a covered service, because it is experimental, investigational, or unproven.
02Do not bill the ancillary laboratory, x-ray, MRI or CT services, infusion pump and intravenous supplies, Hickman catheter placement, or oral antineoplaston therapy and its associated physician services as covered services for the same reason.
03When billing the ICD-10 codes listed as not covered for the indications in this policy (C00.0 - D49.9 neoplasms, G12.21 amyotrophic lateral sclerosis, Z51.0, and Z51.11 - Z51.12), do not report antineoplaston therapy as covered for those indications.

Codes mentioned

C00.0D49.9G12.21Z51.0Z51.11Z51.12

Original notice

Antineoplaston Therapy (CPB 0240, reviewed 2026-04-13)
aetna.com · Always check the source before changing claims.
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