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HumanaMedicare Advantage · Coverage · Medicare Advantage · Endocrinology, General Surgery, Oncology +1 moreMedium impact

Molecular Markers in Fine Needle Aspirates of Thyroid Nodules - Medicare Advantage (Revised)

Effective date
Sep 2, 2025
Identified
Jun 24, 2026

Summary

Humana Medicare Advantage has revised its policy for molecular markers in fine needle aspirates of thyroid nodules, effective September 2, 2025. The policy establishes coverage criteria for molecular diagnostic tests like Afirma Genomic Sequencing Classifier used to evaluate indeterminate thyroid nodules when cytopathology cannot determine if nodules are malignant or benign.

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What to do

Action · 3 steps
01Before September 2, 2025: Billing team must review and understand coverage requirements for thyroid nodule molecular testing under Humana Medicare Advantage plans.
02Ensure documentation supports medical necessity criteria and that tests are ordered by treating physicians for management of specific medical problems.
03Verify applicable LCD/LCA requirements based on geographic jurisdiction as coverage varies by Medicare Administrative Contractor region.

Codes mentioned

81546

Original notice

Molecular Markers in Fine Needle Aspirates of Thyroid Nodules - Medicare Advantage (Revised)
mcp.humana.com · Always check the source before changing claims.
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