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HumanaMedicaid · Coverage · Medicaid · FL · Oncology, Urology, PathologyMedium impact

Gene Expression Profiling for Cancer Indications - MEDICAID - FLORIDA (New)

Effective date
Jun 3, 2025
Identified
Jun 24, 2026

Summary

Humana Florida Medicaid has established a new gene expression profiling policy covering only ConfirmMDx testing for prostate cancer management under specific clinical conditions. Multiple other gene expression profiling tests for various cancers (bladder, breast, lung, colorectal, etc.) are explicitly excluded from coverage due to insufficient evidence.

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What to do

Action · 3 steps
01Before June 3, 2025: Billing team must update Florida Medicaid billing rules to only allow CPT 81551 (ConfirmMDx) for prostate cancer cases meeting specific criteria (atypia suspicious for cancer, benign with clinical suspicion, or high-grade PIN).
02Block all other gene expression profiling codes listed in the exclusions.
03Update prior authorization workflows to verify clinical indications for ConfirmMDx testing.

Codes mentioned

8155181540

Original notice

Gene Expression Profiling for Cancer Indications - MEDICAID - FLORIDA (New)
mcp.humana.com · Always check the source before changing claims.
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