All PlansCoverageMedium impact
Comprehensive Genomic Profiling for Selecting Targeted Cancer Therapies
Blue Cross & Blue Shield of Mississippi·MS · Oncology, Hematology, Pathology·Medical Policy
We identified it
Jun 20, 2026
Summary
This is a comprehensive medical policy defining coverage criteria for expanded genomic profiling panels used to select targeted cancer therapies. The policy distinguishes between established individual genetic markers (not covered by this policy) and expanded molecular panels that test multiple variants without established efficacy for specific cancers.
Action Required
Review current billing practices for comprehensive genomic profiling services to ensure compliance with coverage criteria. Verify that any genomic testing ordered falls under established individual markers or cancer-specific panels rather than expanded panels without proven efficacy. Document medical necessity and ensure appropriate patient selection according to policy guidelines.