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Genetic Testing for Helicobacter Pylori Treatment
Blue Cross & Blue Shield of Mississippi·Gastroenterology, Internal Medicine, Family Medicine·Medical Policy
We identified it
Jun 20, 2026
Summary
BCBS continues to classify genetic testing for CYP2C19 polymorphisms to guide H. pylori treatment as investigational/not covered. This policy remains unchanged from previous versions, meaning CPT code 81225 for CYP2C19 genetic testing will be denied when used for H. pylori treatment planning.
Action Required
No immediate action required. Continue to expect denials for CPT 81225 when billed for H. pylori treatment guidance. Billing team should advise providers that this genetic testing remains non-covered and patients should be informed of potential out-of-pocket costs before testing.