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Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · CardiologyMedium impact

Gene Expression Testing in the Evaluation of Patients with Stable Ischemic Heart Disease

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Gene expression testing in the evaluation of patients with stable ischemic heart disease is considered investigational for all indications, including but not limited to prediction of coronary artery disease in stable, nondiabetic patients. CardioDX has closed operations, and the Corus CAD test is no longer available.

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What to do

Action · 2 steps
01Billing team: Do not bill gene expression testing for stable ischemic heart disease as a medically necessary service, because the policy considers it investigational for all indications.
02CPT 81493 and CPT 84999 (Unlisted chemistry procedure) are listed as the investigational codes.

Codes mentioned

8149384999

Original notice

Gene Expression Testing in the Evaluation of Patients with Stable Ischemic Heart Disease
bcbsms.com · Always check the source before changing claims.
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