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Blue Cross & Blue Shield of MississippiCommercial · Coverage · Medical Policy · MS · Hematology, Oncology, Transplant SurgeryMedium impact

Placental and Umbilical Cord Blood as a Source of Stem Cells

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Transplantation of cord blood stem cells from related or unrelated donors may be considered medically necessary for patients with an appropriate indication for allogeneic stem cell transplant, and it is investigational in all other situations. Collection and storage of a neonate's cord blood may be considered medically necessary when an allogeneic transplant is imminent in an identified recipient with a consistent diagnosis, while prophylactic collection and storage for unspecified future autologous or allogeneic use is considered not medically necessary. No benefits are provided for a covered transplant procedure or transplant evaluation unless the member receives prior authorization through case management from Blue Cross & Blue Shield of Mississippi.

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What to do

Action · 7 steps
01Before a cord blood transplant or transplant evaluation: obtain prior authorization through case management from Blue Cross & Blue Shield of Mississippi, because no benefits are provided for a covered transplant procedure or transplant evaluation without it.
02Bill cord blood stem cell transplantation only for an allogeneic transplant with an appropriate indication, because the policy considers cord blood transplantation investigational in all other situations.
03For State and School Employee subscribers, the Plan's Utilization Review Vendor must certify all bone marrow or stem cell transplants as medically necessary, and no benefits are provided for any transplant unless prior approval is obtained.
04For Federal Employee Program subscribers, the Service Benefit Plan includes specific conditions under which autologous or allogeneic transplants are eligible for coverage.
05Collection and storage of neonatal cord blood is medically necessary only when an allogeneic transplant is imminent in an identified recipient with a diagnosis consistent with the possible need for allogeneic transplant.
06When Blue Cross & Blue Shield of Mississippi requests medical records, letters of support or explanation are often useful but are not sufficient unless all specific information needed to make a medical necessity determination is included.
07Services not documented to be medically necessary are not paid.

Codes mentioned

3824086812868138681686817868218682586826S2140S2142S2150

Original notice

Placental and Umbilical Cord Blood as a Source of Stem Cells
bcbsms.com · Always check the source before changing claims.
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Related changes

See all Blue Cross & Blue Shield of Mississippi changes →
Nonmyeloablative Allogeneic Transplants of Hematopoietic Stem-Cells for Treatment of MalignancyMediumNo effective date · Medical PolicyHematopoietic Cell Transplantation for Miscellaneous Solid Tumors in AdultsMediumNo effective date · Medical PolicyHematopoietic Cell Transplantation in the Treatment of Germ Cell TumorsMediumNo effective date · Medical PolicyHematopoietic Cell Transplantation for Non-Hodgkin LymphomasMediumNo effective date · Medical PolicyBrowse every Blue Cross & Blue Shield of Mississippi change in the policy list

Related policy hubs

Blue Cross & Blue Shield of Mississippi policiesMS policy changesHematologyOncologyTransplant SurgeryCode 38240Code 86812Code 86813Code 86816Code 86817Code 86821Code 86825Code 86826Code S2140Code S2142Code S2150

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