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Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · Genetics, Hematology, PathologyMedium impact

Genetic Testing for Inherited Thrombophilia

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Genetic testing for inherited thrombophilia, including testing for the factor V Leiden variant, prothrombin gene variants, and variants in the MTHFR gene, is considered investigational. The policy history records a 09/01/2026 update to the policy description regarding the factor V Leiden mutation, and the policy statement is unchanged.

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What to do

Action · 2 steps
01Billing team: Before billing genetic testing for inherited thrombophilia (factor V Leiden, prothrombin G20210A variant, or MTHFR variants), note that the policy considers this testing investigational and not considered medically necessary.
02The policy lists CPT 0529U, 81240, 81241 and 81291 under Investigational Codes.

Codes mentioned

812408124181291

Original notice

Genetic Testing for Inherited Thrombophilia
bcbsms.com · Always check the source before changing claims.
View original ↗

Related changes

See all Blue Cross & Blue Shield of Mississippi changes →
Pharmacogenetic Testing for Pain ManagementMediumNo effective date · Medical PolicyBrowse every Blue Cross & Blue Shield of Mississippi change in the policy list

Related policy hubs

Blue Cross & Blue Shield of Mississippi policiesGeneticsHematologyPathologyCode 81240Code 81241Code 81291

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