Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · Cardiology, RadiologyMedium impact
Coronary Computed Tomography Angiography with Selective Noninvasive Fractional Flow Reserve
Effective date
Not stated in the notice
Identified
Jun 20, 2026
Summary
Noninvasive fractional flow reserve following a positive coronary computed tomography angiography may be considered medically necessary to guide decisions about invasive coronary angiography for individuals with stable chest pain and intermediate risk of coronary artery disease (suspected or presumed stable ischemic heart disease). Noninvasive fractional flow reserve that does not meet these criteria is considered investigational. The 10/16/2026 update revised the policy description regarding the Heartflow Analysis and made minor changes to the medically necessary statement.
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01Billing team: Before billing noninvasive fractional flow reserve (CPT 75580) after a positive coronary computed tomography angiography, confirm the individual has stable chest pain and intermediate risk of coronary artery disease (suspected or presumed stable ischemic heart disease).
02The policy considers noninvasive fractional flow reserve that does not meet these criteria investigational.
03The listed medically necessary codes are CPT 75580 with ICD-10 codes I20.9, I25.112, I25.118, I25.119, I25.752, I25.758 and I25.759, and these codes are ONLY medically necessary if the procedure is performed according to the policy section.
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