All PlansCoverageLow impact
Genetic Testing for Li-Fraumeni Syndrome
Blue Cross & Blue Shield of Mississippi·MS · Oncology, Family Medicine, Internal Medicine +2 more·Medical Policy
We identified it
Jun 20, 2026
Summary
This is a new medical policy establishing coverage criteria for genetic testing for Li-Fraumeni Syndrome, a rare cancer predisposition syndrome caused by TP53 gene mutations. The policy defines clinical criteria (Classic LFS and Chompret criteria) that must be met for coverage of genetic testing in probands and at-risk family members.
Action Required
Immediately: Review patient cases for Li-Fraumeni Syndrome genetic testing requests to ensure they meet either Classic LFS criteria or Chompret criteria before submitting claims. Document family history and clinical presentation according to the specified criteria. Claims not meeting these clinical guidelines may be denied.