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Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · RheumatologyMedium impact

Anti-CCP Testing for Rheumatoid Arthritis

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Measurement of anti-CCP may be considered medically necessary when used as part of the diagnostic work-up for rheumatoid arthritis, up to two times per calendar year. Measurement of anti-CCP is considered investigational when used to monitor disease activity or treatment response. The covered code is CPT 86200, paired with covered ICD-10 diagnosis codes for rheumatoid arthritis and other unspecified arthropathy, juvenile arthritis, pain in joint, and stiffness of joint.

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What to do

Action · 3 steps
01Billing team: For CPT 86200, claims for the diagnostic work-up of rheumatoid arthritis may be medically necessary up to two times per calendar year.
02Anti-CCP measurement used to monitor disease activity or treatment response is considered investigational under this policy.
03Use the covered ICD-10 diagnosis codes in the code reference when billing CPT 86200: M05.00 through M08.99, M12.00 through M12.09 (rheumatoid arthritis and other unspecified arthropathy), M08.9A (juvenile arthritis, unspecified, other specified site), M25.50 through M25.579 (pain in joint), M25.59 (pain in other specified joint), M25.60 through M25.676 (stiffness of joint), and M25.69 (stiffness of other specified joint).

Codes mentioned

86200M05.00M08.99M12.00M12.09M08.9AM25.50M25.579M25.59M25.60M25.676M25.69

Original notice

Anti-CCP Testing for Rheumatoid Arthritis
bcbsms.com · Always check the source before changing claims.
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