Summary
BNP or NT-proBNP may be considered medically necessary for the diagnosis and treatment of congestive heart failure, or when performed in the first few days following an acute coronary event for risk stratification. Routine screening with BNP or NT-proBNP is considered investigational. The 10/01/2026 update added cardiomyopathy codes I42.00, I42.01, I42.09, I42.81 and I42.89 to the code reference, and I42.0 was deleted as of 09/30/2026.
Get alerts when payers change rules like this one
We check Blue Cross & Blue Shield of Mississippi and other payers every day and email you when a change matches your specialty and state.
Get Blue Cross & Blue Shield of Mississippi alertsPolicy Monitoring is free. No card required.
What to do
Action · 3 steps
01Already effective 2026-10-01: Cardiomyopathy codes I42.00, I42.01, I42.09, I42.81 and I42.89 were added to the code reference, and I42.0 was deleted as of 09/30/2026.
02Billing team: Check that cardiomyopathy diagnosis codes on BNP or NT-proBNP claims are on the updated code list.
03Billing team: Confirm that the test was ordered for diagnosis or treatment of congestive heart failure, or for risk stratification in the first few days after an acute coronary event, because routine screening is considered investigational.
Codes mentioned
83880I42.0I42.00I42.01I42.09I42.81I42.89
Original notice
B-Natriuretic Peptide
bcbsms.com · Always check the source before changing claims.
Related changes
See all Blue Cross & Blue Shield of Mississippi changes →Genetic Testing for Idiopathic Dilated CardiomyopathyHighEffective Oct 1, 2026 · Medical PolicyImplantable Cardioverter DefibrillatorHighEffective Oct 1, 2026 · Medical PolicyHeart TransplantHighEffective Oct 1, 2026 · Medical PolicyMedically Indicated Early-Term Deliveries (Prior to 39 Weeks)MediumEffective Oct 1, 2026 · Medical PolicyBrowse every Blue Cross & Blue Shield of Mississippi change in the policy list