CommercialCoverageMedium impact
Analysis of Human DNA in Stool Samples as a Technique for Colorectal Cancer Screening
Blue Cross & Blue Shield of Mississippi·MS · Family Medicine, Internal Medicine, General Practice +1 more·Medical Policy
Effective date
Mar 31, 2025
We identified it
Jun 20, 2026
Summary
Blue Cross Blue Shield of Mississippi updated their colorectal cancer screening policy to include the new Cologuard Plus test, which FDA approved on October 3, 2024. Exact Sciences Corporation plans to phase out the original Cologuard test on March 31, 2025, replacing it with Cologuard Plus under the same coverage criteria.
Action Required
Before March 31, 2025: Billing team must update systems to recognize Cologuard Plus as covered under the same criteria as original Cologuard for colorectal cancer screening. Verify correct HCPCS coding for Cologuard Plus claims. Remind providers that members will have out-of-network cost-sharing since Exact Sciences Corporation is not a BCBS Mississippi network provider.