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Blue Cross & Blue Shield of MississippiCommercial · Coverage · Medical Policy · MS · Neurology, GeneticsMedium impact

State and School Employees' Health Insurance Plan - Duchenne Muscular Dystrophy (DMD)

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Elevidys (delandistrogene moxeparvovec-rokl) may be considered medically necessary as a single-dose intravenous infusion for Duchenne muscular dystrophy (DMD) when all listed criteria are met. Amondys 45 (casimersen), Exondys 51 (eteplirsen), Viltepso (viltolarsen), and Vyondys 53 (golodirsen) are considered investigational for DMD because there is insufficient evidence of clinical benefit. The most recent review, dated 02/24/2026, updated the Elevidys description to remove the non-ambulatory indication.

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What to do

Action · 7 steps
01REQUIREMENTS: Billing team: Search the State Health Plan Medical Drug Formulary for drugs administered and billed through the medical setting before billing Elevidys (delandistrogene moxeparvovec-rokl).
02For Elevidys, the member must be more than 4 years of age at the time of infusion, must have a confirmed mutation in the DMD gene, must not have any deletion in exon 8 and/or exon 9 in the DMD gene, and must have a corticosteroid regimen for a minimum of 60 days initiated one day prior to infusion.
03The prescribed dosage must be within the program quantity limits based on the FDA approved labeled dosage.
04Length of approval is 1 infusion per lifetime (weight based).
05Amondys 45, Exondys 51, Viltepso, and Vyondys 53 are considered investigational for DMD, and their HCPCS codes J1426, J1427, J1428, J1429, and J3490 are listed in the policy's Investigational Codes table.
06Services related to delivery or administration of a medication determined to be not medically necessary will also be considered not medically necessary.
07Services not documented as medically necessary will not be paid.

Codes mentioned

J1413G71.01J1426J1427J1428J1429J3490

Original notice

State and School Employees' Health Insurance Plan - Duchenne Muscular Dystrophy (DMD)
bcbsms.com · Always check the source before changing claims.
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