CommercialCoverageHigh impact
Intra-articular Hyaluronan Injections for Osteoarthritis
Blue Cross & Blue Shield of Mississippi·MS · Orthopedics, PM&R (Physical Medicine & Rehab), Sports Medicine +3 more·Medical Policy
We identified it
Jun 20, 2026
Summary
BCBS Mississippi significantly restricted coverage for hyaluronic acid knee injections, now covering only Durolane and Euflexxa while excluding 13 other brands from their formulary. All other joint injections (hip, shoulder, etc.) remain investigational and non-covered.
Action Required
Immediately: Update billing system to flag that only Durolane and Euflexxa are covered for knee osteoarthritis injections for BCBS MS patients. All other hyaluronic acid products (Gel-One, Gelsyn-3, GenVisc 850, Hyalgan, Hymovis, Monovisc, Orthovisc, Supartz FX, Synojoynt, Synvisc, Synvisc One, Triluron, TriVisc, Visco-3) are not covered. Stop billing hyaluronic acid injections for any joint other than the knee. Providers must document insufficient pain relief from conservative therapy before injection and wait 6 months between repeat courses.