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Blue Cross & Blue Shield of MississippiAll Plans · Coverage · Medical Policy · Neurology, GeriatricsHigh impact

Evaluation of Biomarkers for Alzheimer Disease

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Cerebrospinal fluid testing of amyloid beta peptides and tau protein is medically necessary as part of an evaluation for starting amyloid beta targeting therapy in individuals with mild cognitive impairment or mild dementia due to Alzheimer disease, a change the policy history dates to 06/15/2025. CSF neural thread protein testing for that purpose, CSF biomarker testing as an adjunct to clinical diagnosis, CSF testing for continuing amyloid beta targeting therapy, and urinary and blood biomarker testing as an adjunct to clinical diagnosis are investigational. This is and the latest change note in the policy is dated 04/01/2026.

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What to do

Action · 5 steps
01Billing team: For CSF testing of amyloid beta and tau done as part of an evaluation for starting amyloid beta targeting therapy in individuals with mild cognitive impairment or mild dementia due to Alzheimer disease, the medically necessary CPT codes are 82233, 82234, 84393 and 84394, listed with ICD-10 codes G30.0 through G30.9 (Alzheimer's disease).
02Billing team: Services the policy considers investigational are not considered medically necessary.
03These include CSF neural thread protein testing for starting therapy, CSF biomarker testing as an adjunct to clinical diagnosis, CSF testing for continuing therapy, and urinary and blood biomarker testing as an adjunct to clinical diagnosis.
04Billing team: BCBSMS makes no payment for services not documented to be medically necessary, and a physician's order does not in itself make a service medically necessary.
05Providers: The policy guidelines state that the labels for LEQEMBI (lecanemab) and Kisunla (donanemab) call for confirming the presence of amyloid beta pathology before treatment is started, so documentation should reflect that confirmation.

Codes mentioned

82233822348439384394G30.0G30.9

Original notice

Evaluation of Biomarkers for Alzheimer Disease
bcbsms.com · Always check the source before changing claims.
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Related changes

See all Blue Cross & Blue Shield of Mississippi changes →
Selected Positron Emission Tomography Technologies for Evaluation of Alzheimer DiseaseHighNo effective date · Medical PolicyMagnetic Resonance Imaging (MRI) of the Brain and HeadHighEffective Oct 1, 2026 · Medical PolicyGenetic Testing for Alzheimer DiseaseMediumNo effective date · Medical PolicyState and School Employees' Health Insurance Plan - Monoclonal Antibodies for Treatment of Alzheimer’s DiseaseHighNo effective date · Medical PolicyBrowse every Blue Cross & Blue Shield of Mississippi change in the policy list

Related policy hubs

Blue Cross & Blue Shield of Mississippi policiesNeurologyGeriatricsCode 82233Code 82234Code 84393Code 84394Code G30.0Code G30.9

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