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Confocal Laser Endomicroscopy
Effective date
Not stated in the notice
Identified
Jun 20, 2026
Summary
Use of confocal laser endomicroscopy is considered investigational under this policy. The policy describes two FDA-cleared systems, the Cellvizio probe-based system and the Pentax Confocal Video Colonoscope, and states that the Pentax device is no longer commercially available from the manufacturer. CPT 43206, 43252 and 88375 are listed under Investigational Codes. The Federal Employee Program may dictate that FDA-approved devices are not considered investigational and are assessed only on medical necessity.
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What to do
Action · 3 steps
01Billing team: Treat CPT 43206, 43252 and 88375 as investigational codes, since the policy lists them under Investigational Codes and states that use of confocal laser endomicroscopy is investigational.
02Under the policy definition, investigative services are not considered medically necessary.
03For Federal Employee Program subscribers, FDA-approved devices may be assessed only on medical necessity.
Codes mentioned
432064325288375
Original notice
Confocal Laser Endomicroscopy
bcbsms.com · Always check the source before changing claims.