Siltuximab (Sylvant) (CPB 0884, reviewed 2026-06-03)
Aetna covers siltuximab (Sylvant) for commercial medical plans when it is used for multicentric Castleman's disease that is HIV-1 negative and HHV-8 negative, for relapsed, refractory or progressive unresectable unicentric Castleman's disease that is HIV-1 negative and HHV-8 negative, and for specific cytokine release syndrome cases, including grade 4 CAR T-cell-induced cytokine release syndrome that is refractory to high-dose corticosteroids and anti-IL-6 therapy. Continuation of therapy is covered when there is no evidence of unacceptable toxicity or disease progression while on the current regimen. Aetna considers all other indications experimental, investigational, or unproven, including breast cancer, multiple myeloma, rheumatoid arthritis and COVID-19.