Risk-Reducing Mastectomy
Risk-reducing mastectomy may be considered medically necessary for individuals at high risk of breast cancer, including those with lobular carcinoma in situ, a known BRCA1 or BRCA2 variant, another high-risk gene variant such as TP53, PTEN, CDH1, STK11 or PALB2, or chest radiotherapy before 30 years of age. It is considered investigational for all other indications, including contralateral risk-reducing mastectomy in individuals with breast cancer who do not meet high-risk criteria. On 10/01/2026 the code reference was updated to add ICD-10 diagnosis codes QA1.790, QA1.791 and QA1.792.