Oral and Esophageal Brush Biopsy (CPB 0686, reviewed 2026-10-15)
Aetna Clinical Policy Bulletin 0686 on oral and esophageal brush biopsy was last reviewed on 10/15/2026. It considers oral brush biopsy (OralCDx) with or without MAGE-A or GLUT-1 staining, esophageal brush biopsy (WATS3D, formerly EndoCDx), DNA-image cytometry, RNA-based oral brush biopsy, salivary miRNAs and esophageal balloon cytologic sampling experimental, investigational or unproven because their effectiveness has not been established, for screening, diagnosis or surveillance. The policy lists CPT 88104 and 99000, HCPCS D0486 and D7288, and several ICD-10 codes, including Z12.81, as not covered for the indications it lists.