Corneal Graft and Amniotic Membrane Transplantation, Corneal Stromal Lenticule Transplantation, Limbal Stem Cell Transplantation, or Sural Nerve Grafting for Ocular Indications (CPB 0293, reviewed 2026-06-08)
Aetna considers preserved human amniotic membrane or limbal stem cell transplantation medically necessary for ocular surface reconstruction in members with limbal deficiency that is refractory to conventional treatment, when the member has a listed condition such as chemical or thermal injury of the ocular surface, Stevens-Johnson syndrome, bacterial keratitis, bullous keratopathy, or pterygium. More than 3 applications per eye of any human amniotic membrane graft for ophthalmic indications is considered not medically necessary, and an additional three applications per eye per year in each subsequent year may be medically necessary for chronic or recurrent ophthalmic conditions. Allogeneic corneal epithelial stem cell transplantation is listed as experimental, investigational, or unproven, and amniotic membrane placement for recurrent corneal erosions in epithelial basement membrane dystrophy is considered not medically necessary.