Intra-oral Appliances for Headaches and Trigeminal Neuralgia (CPB 0688, reviewed 2026-10-14)
Aetna considers intra-oral appliances, such as the Nociceptive Trigeminal Inhibition-Tension Suppression System, experimental, investigational, or unproven for treating headaches and trigeminal neuralgia, because the effectiveness of this approach for these indications has not been established. CPT 21110 and HCPCS codes for occlusal guards, removable appliance therapy, custom sleep apnea appliances, and oral appliance therapy are listed as not covered for the indications in this policy. Diagnosis codes for migraine, other headache syndromes, trigeminal neuralgia, and headache are also listed as not covered for the indications in this policy.