Valoctocogene Roxaparvovec-rvox (Roctavian) (CPB 1037, reviewed 2026-04-20)
Aetna covers one dose of valoctocogene roxaparvovec-rvox (Roctavian) for severe hemophilia A when the member meets its initial approval criteria. These include age 18 or older, factor VIII activity of 1 IU/dL or less, no pre-existing AAV5 antibodies confirmed by an FDA-approved test, and at least 150 exposure days of prophylactic factor VIII use. The drug must be prescribed by or in consultation with a hematologist, and Aetna considers all other indications experimental, investigational or unproven.