Lymphangioma and Infantile Hemangioma (CPB 0817, reviewed 2025-12-03)
Treatment of hemangiomas of infancy is medically necessary when the lesion compromises vital structures such as the nose, eyes, ears, lips or larynx, is associated with Kasabach-Merritt Syndrome, is symptomatic, or results in a documented functional impairment, using cryosurgery or cryotherapy, embolization, intralesional steroids, laser therapy, radiotherapy, sclerosing therapy or surgical excision alone or in combination. Oral propranolol for proliferating infantile hemangioma requiring systemic therapy (corticosteroids) is medically necessary, and inpatient initiation is medically necessary for infants 8 weeks or younger (corrected age), infants without adequate social support, and infants with co-morbid cardiovascular, airway or blood glucose conditions. Atenolol, pigment epithelium-derived factor, topical timolol, C19MC microRNA and serum VEGF biomarker measurements, and sirolimus for diffuse intestinal infantile hemangioma are considered experimental, investigational or unproven.