Oncologic Applications of Photodynamic Therapy, Including Barrett Esophagus
Photodynamic therapy may be considered medically necessary for palliative treatment of obstructing esophageal cancer, palliative treatment of obstructing endobronchial lesions, early-stage non-small-cell lung cancer in individuals ineligible for surgery and radiotherapy, high-grade dysplasia in Barrett esophagus, and palliative treatment of unresectable cholangiocarcinoma when used with stenting. Other oncologic applications, including Barrett esophagus without high-grade dysplasia, are investigational. The policy history records a 09/12/2025 description update, with policy guidelines updated regarding focal therapy.