Afamelanotide (Scenesse) (CPB 0962, reviewed 2025-12-09)
Aetna considers afamelanotide (Scenesse) medically necessary for biochemically confirmed erythropoietic protoporphyria in adult members whose protoporphyrin level is above the lab reference range in peripheral red blood cells. Aetna considers continuation of afamelanotide therapy medically necessary for adult members with that indication who are experiencing benefit from therapy while receiving it. Aetna considers all other indications experimental, investigational, or unproven, including inhibition of drug-resistant pathogenic bacteria such as MRSA and treatment of acute ischemic stroke, and this policy applies to commercial medical plans.