CommercialCoverageMedium impact
Physiologic Insulin Resensitization (PIR)
Blue Cross & Blue Shield of Mississippi·MS · Endocrinology, Internal Medicine, Family Medicine·Medical Policy
We identified it
Jun 20, 2026
Summary
BCBS Mississippi has established a new policy classifying Physiologic Insulin Resensitization (PIR) as investigational for all indications, meaning it will not be covered due to insufficient evidence of clinical benefit. The policy affects insulin infusion treatments using programmable pumps with pulsatile dosing combined with glucose administration.
Action Required
Immediately: Billing team must flag all claims for Physiologic Insulin Resensitization (PIR) treatments as non-covered investigational procedures. Update billing system to deny/reject claims using CPT codes 96365, 96366, 96367, 96521, J1815, and J1817 when used for PIR treatments. Notify providers that PIR is considered investigational and not covered by BCBS Mississippi.