CommercialPrior AuthMedium impact
08.00.12h, Fam-trastuzumab deruxtecan-nxki (Enhertu®)
Independence Blue Cross·Oncology, Pharmacy·Pharmacy
Effective date
Jun 16, 2025
We identified it
Jun 19, 2026
Summary
Medical necessity criteria have been updated for Fam-trastuzumab deruxtecan-nxki (Enhertu®), a HER2-directed antibody-drug conjugate used in oncology. The billing team must review updated approval requirements and documentation standards for this pharmacy benefit effective immediately.
Action Required
By June 16, 2025: Billing and prior authorization teams must review the full policy text at the provided URL to identify specific medical necessity criteria for Enhertu® claims. Update prior authorization protocols and supporting documentation requirements in the billing system. Ensure providers submitting claims for this drug include all required clinical documentation per the new criteria. Contact the payer or access the full policy to determine if prior authorization is required and what clinical indicators must be documented. Claims submitted without proper documentation per updated criteria may be denied.