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2025 November Medical Policy Updates

BlueCross BlueShield of South Carolina·SC · Genetics, Infectious Disease, Oncology +12 more·Medical Policy
Effective date
Nov 1, 2025
We identified it
Aug 20, 2026
Days to comply

Summary

BlueCross BlueShield of South Carolina and BlueChoice HealthPlan released 35 medical policy updates effective November 2025, including one new policy (CAM 397 Psychological and Neuropsychological Testing), multiple CPT code removals and additions across testing and diagnostic services, and coverage criteria changes for HIV testing/PrEP, genetic testing, minimal residual disease, and diagnostic procedures. Billing teams must immediately update systems to remove deprecated codes and implement new coverage requirements.

Action Required

Action needed
Immediately (effective November 2025): (1) Billing team must REMOVE the following CPT/HCPCS codes from all billing systems and encounter forms: 82565, 82575, 84703, 86701, 86702, 86703, 86705, 86803, 86804, 87660, 0500T, G0432, G0433, G0435, G0475, S3645, 87661, 87808, and 87631. (2) ADD new codes 87626, 87800, 87164, and 87166 to billing systems with appropriate policy associations (CAM 209, CAM 210). (3) Update billing software logic for CAM 282 (HIV Testing) to require prior authorization documentation for PrEP coverage and implement new testing frequency limits. (4) Implement new coverage criteria in CAM 161 (Lumbar Spine Procedures): update lumbar fusion revision surgery definition from 6-12 months to 9-12 months following failed operation. (5) Add tobacco/nicotine use contraindication check in billing system for CAM 389 (Lumbar Artificial Disc Replacement). (6) Update CAM 10116 (Negative Pressure Wound Therapy) billing rules: change initial trial period authorization from 14 days to 30 days. (7) For CAM 251 (Minimal Residual Disease), add diffuse large B-cell lymphoma (DLBCL) to coverage criteria. (8) Providers must document updated NCCN guideline alignment for CAM 169 (Lynch Syndrome Testing) and CAM 261 (BRCA genetic testing). (9) Front desk and intake staff must add new documentation checklist for CAM 335 (Alzheimer/dementia biomarkers) including p-tau CSF testing eligibility. (10) Verify all claims submitted with deleted codes will be denied; resubmit with appropriate replacement codes. CONSEQUENCES: Claims using removed codes will be rejected; PrEP claims without proper authorization will be denied; lumbar surgery pre-authorizations submitted with old 6-month criteria will require amendment.

Affected Billing Codes

82565
82575
84703
86701
86702
86703
86705
86803
86804
87660
G0432
G0433
G0435
G0475
S3645
87626
87800
87661
87808
87164
87166
87631