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Breast Biopsy Procedures (CPB 0269, reviewed 2026-05-14)

Aetna·Radiology, General Surgery, Oncology +1 more·Medical Policy
Effective date
May 14, 2026
We identified it
Aug 14, 2026
Days to comply

Summary

Aetna's updated breast biopsy policy (CPB 0269, effective 2026-05-14) clarifies coverage for minimally invasive image-guided breast biopsy procedures as medically necessary alternatives when BI-RADS category 4 or 5 lesions are detected. The policy also explicitly designates several newer technologies (pegulicianine fluorescence, magnetic seeds, SAVI SCOUT, MarginProbe) as experimental/investigational and NOT covered. Billing teams must ensure claims for covered biopsy codes (19081-19086, 19283-19288) meet BI-RADS criteria, and reject claims for non-covered experimental procedures.

Action Required

Action needed
By May 14, 2026: Billing team must implement the following changes in the billing system: (1) Configure CPT codes 19081-19086 and 19283-19288 to require documentation of BI-RADS category 4 or 5 findings before claims are submitted to Aetna. (2) Create automated rejection rules for experimental/non-covered codes: 0546T (RadioFrequency spectroscopy/MarginProbe), 0945T (pegulicianine/Lumisight fluorescence), 76376-76377 (3D volumetric imaging), and any claims mentioning magnetic seeds (Magseed), SAVI SCOUT surgical guidance, or tomosynthesis-guided RFID localizer placement. (3) Update claim scrubbing logic to flag any breast biopsy/localization claims (19281-19288) that lack documentation of imaging modality (mammographic, stereotactic, ultrasound, or MR guidance) as BI-RADS indicator. (4) Communicate to providers and radiology partners that digital breast tomosynthesis-guided biopsy is now an acceptable alternative to mammographically-guided biopsy. (5) Update encounter templates and prior authorization forms to prompt for BI-RADS category verification. Providers should submit claims with operative notes documenting lesion characteristics (BI-RADS 4 or 5 status). Failure to include required documentation will result in denials for covered codes; claims for experimental procedures will be denied automatically.

Affected Billing Codes

19081
19082
19083
19084
19085
19086
19281
19282
19283
19284
19285
19286
19287
19288
76942
77061
77062
77063
76376
76377
10005
10006
10007
10008
10011
10012
10021
19100
19101
19120
19121
19122
19123
19124
19125
19126
19296
19297
19298
19301
19302
76098
76641
76642
77002
77011
77012
77021
77046
77047
77048
77049
77053
77054
77065
77066
77067
96365