By October 1, 2025: (1) Billing team must configure system edits to deny claims for CPT codes 36511, 86357, 88230, 88237, 88239 and HCPCS codes S2107 and M0075 when paired with any ICD-10 diagnosis codes listed in the policy (A00.0–B99.9, C00.0–D09.9, E85.0–E85.9, G30.0–G30.9, G72.41 for adoptive immunotherapy; B20, B25.9–B34.9, C00.0–D09.9, E08.00–E13.9, G10, G12.20–G12.29, I10–I16.9, I20.1–I20.9, I21.01–I22.9, I24.0–I25.9, I42.8, I50.1–I50.9, I63.50–I63.9, I70.0–I70.92, I73.00–I73.9, I74.2–I74.4, I75.011–I75.029, I80.00–I80.209, I82.401–I82.5Z9, I99.9, J45.20–J45.998, K57.00–K57.93, M00.00–M99.9, N18.1–N18.9, N46.01, N46.021–N46.029, P27.1, R53.82, S06.0X0A–S06.A1XS, U07.1, Z94.0 for cellular therapy; and A08.0–A08.8, A80–A89, A90–A98, B00–B09, B10.01–B10.89, B15–B19, B20, B25–B34, B97.0–B97.8 for virus-specific T-cell lymphocyte therapy). (2) Providers must be notified that these therapies are non-covered for the listed indications; update provider communications and billing guidance documents. (3) Update denial reason codes in billing system to reference CPB 0641. (4) Front desk staff should flag requests for these services during registration to alert providers and billing staff. Claims submitted without prior awareness will be denied at adjudication; proactive system configuration will prevent unnecessary claim submission and rework.