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Allergy and Hypersensitivity (CPB 0038, reviewed 2026-03-10)

Aetna·Allergy & Immunology, Internal Medicine, Pediatrics +2 more·Medical Policy
Effective date
Mar 10, 2026
We identified it
Aug 12, 2026
Days to comply

Summary

Aetna updated its Allergy and Hypersensitivity clinical policy (CPB 0038, replacing CPB 326) effective March 10, 2026. This policy establishes medical necessity criteria for allergy testing (skin tests, in vitro IgE tests, patch testing, challenge tests), specifies maximum test quantities allowed, restricts duplicate testing modalities, and defines coverage for allergy immunotherapy and rapid desensitization. Billing teams must ensure claims align with these strict criteria or face denials.

Action Required

Action needed
By March 10, 2026: Billing team must implement the following compliance measures: (1) Update billing system edits to enforce maximum test limits (70 percutaneous + 40 intradermal for inhalant testing; 40 in vitro tests for inhalant screening; 12 for food/other; up to 80 patch tests; up to 14 SET titration tests); (2) Configure system to DENY claims when BOTH percutaneous allergy tests AND IgE RAST tests are billed for identical allergens (not medically necessary per policy); (3) Require documentation in claims showing symptoms inadequately controlled by conservative therapy before approving allergy testing; (4) Add verification step that testing correlates to member's history, exposure risk, and physical findings; (5) Deny routine allergy re-testing unless new sensitivities emerge during/after immunotherapy or immunotherapy has failed; (6) Restrict repeated percutaneous testing to monitor immunotherapy response (not covered); (7) Ensure immunotherapy claims include documentation of severe IgE-dependent symptoms AND either skin/serologic evidence of IgE antibodies OR life-threatening insect sting allergy or allergen management failure; (8) Deny rapid desensitization claims except for drug allergies without alternatives, insect sting hypersensitivity, or moderate-severe rhinitis during allergy season when other treatments failed; (9) Route all claims for Ara h 2 testing and alpha-gal allergy testing only when specific clinical triggers documented (urticaria, angioedema, anaphylaxis, GI symptoms with syncope for alpha-gal; suspected peanut allergy for Ara h 2); (10) Providers must attach clinical documentation showing medical necessity criteria met; (11) Front desk staff should update encounter forms to include checkboxes for conservative therapy failure and documented IgE-mediated symptoms. Failure to implement these edits will result in high claim denial rates and member complaints.