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Coverage for Casgevy (J3392) and Lyfgenia (J3394) for the Sickle Cell Gene Therapy Model

Arkansas Medicaid·AR · Hematology, Oncology, Pharmacy +1 more·Pharmacy
Effective date
Mar 24, 2026
We identified it
Mar 24, 2026
Days to comply

Summary

Arkansas has issued a new pharmacy coverage policy for Casgevy (J3392) and Lyfgenia (J3394), two gene therapy medications for sickle cell disease. This policy establishes coverage parameters and billing requirements for these specialty drugs under the Sickle Cell Gene Therapy Model, effective immediately.

Action Required

Action needed
Immediately: Billing team must update billing system to recognize and process HCPCS codes J3392 (Casgevy) and J3394 (Lyfgenia) for Arkansas Medicaid claims. Review the full policy document at https://humanservices.arkansas.gov/wp-content/uploads/ON-007-26.docx to identify any prior authorization requirements, medical necessity documentation needs, or coverage limitations. Update claims submission protocols and provider education materials to reflect new billing codes and any coverage restrictions. Failure to bill correctly may result in claim denials or delays for sickle cell gene therapy patients.

Affected Billing Codes

J3392
J3394