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Medicare AdvantagePrior AuthLow impact

Miplyffa® (arimoclomol) (Revised)

Humana·Neurology, Genetics, Pediatrics·Medicare Advantage
Effective date
Mar 26, 2025
We identified it
Jun 24, 2026
Days to comply

Summary

Humana Medicare Advantage now requires prior authorization for Miplyffa (arimoclomol) for treatment of Niemann-Pick disease type C. This ultra-rare disease medication requires specific diagnostic confirmation, combination with miglustat, and specialist prescribing to obtain coverage approval.

Action Required

Action needed
By March 26, 2025: For any patients with Niemann-Pick disease type C requiring Miplyffa, billing team must ensure providers obtain prior authorization from Humana Medicare Advantage before prescribing. Verify all five criteria are met: confirmed NPC diagnosis with genetic/lab testing, combination with miglustat, neurological symptoms present, and specialist prescribing. Visit www.humana.com/PAL for prior authorization submission process.