Medicare AdvantagePrior AuthLow impact
Siklos (hydroxyurea) tablet (New)
Humana·Hematology, Oncology, Pediatrics +1 more·Medicare Advantage
Effective date
Jan 1, 2026
We identified it
Jun 24, 2026
Summary
Humana Medicare Advantage now requires prior authorization for Siklos (hydroxyurea) tablets used to treat sickle cell anemia, effective January 1, 2026. Patients must have failed or been intolerant to both hydroxyurea capsules AND L-glutamine oral packets before Siklos will be approved.
Action Required
Before January 1, 2026: Billing team must update prior authorization workflow for Siklos (hydroxyurea) tablets for Humana Medicare Advantage patients. Ensure providers document diagnosis of sickle cell anemia and previous treatment failures/intolerances with hydroxyurea capsules AND L-glutamine oral packets. Submit prior authorization requests through Humana's system before prescribing Siklos.