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Readmission Policy and Genetic Testing Updates

Blue Cross Blue Shield of Nebraska·NE · Genetics, Oncology, Cardiology +2 more·Medical Policy
Effective date
Jan 1, 2024
We identified it
Jun 24, 2026
Days to comply

Summary

Blue Cross Blue Shield of Nebraska updated multiple medical policies effective January 1, 2024, adding new preauthorization requirements for genetic testing, cardiac transplant rejection testing, and oncology molecular profiling, while establishing new coverage criteria for various genetic and molecular tests.

Action Required

Action needed
Immediately: Billing team must update system to require preauthorization for all listed genetic testing codes (81271, 81274, 81222, 81223, 81442), cardiac transplant rejection testing (0087U), oncology molecular profiling (81542, 0047U, 81541, 0177U, 81309, 81445, 81455, and others), and exome sequencing codes (81415, 81416, 0214U, 0215U). Update encounter forms to alert providers that preauth is required. Review medical necessity criteria for each test type and ensure documentation meets new policy requirements. Claims without proper preauthorization will be denied.

Affected Billing Codes

81271
81274
81415
81416
81222
81223
81442
81542
81541
81309
81445
81455
81449
81451
81456
81420
81507