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Site of Care Guidelines Expansion: Select Oncology and Non-Oncology Provider-Administered Medications

Florida Blue·FL · Oncology, Hematology, Endocrinology +3 more·Provider Bulletin
Effective date
Jul 1, 2026
We identified it
Jun 23, 2026
Days to comply
8 days

Summary

Florida Blue is expanding Site of Care Guidelines effective July 1, 2026, requiring select oncology immunotherapies (when used as monotherapy) and non-oncology provider-administered medications to be given at alternative sites instead of outpatient hospital facilities unless specific criteria are met. This affects members whose benefit plans include comparative effectiveness in medical necessity definitions and will require prior authorization reviews to determine appropriate administration sites.

Action Required

Before Jul 1, 2026
By July 1, 2026: Billing team must update prior authorization processes for listed HCPCS codes to include site of care determination. Providers must initiate conversations with Florida Blue patients receiving these medications at hospital outpatient facilities before current prior authorizations expire. Contact Prime MPS at 1-800-424-4947 for transition assistance. Claims for hospital outpatient administration may be denied unless specific criteria are met (pediatric patients under 18, lack of alternative site access, distance >45 miles from alternatives, or documented clinical conditions requiring enhanced supervision).

Affected Billing Codes

J0219
J0222
J0224
J0256
J0257
J0491
J0584
J0638
J0791
J0896
J1305